Post-chemotherapy Symptom Management: Testing Intervention Sequences in a SMART Design
The SMART (randomized sequential assignment) trial design incorporates two interventions with proven efficacy: symptom assessment and referral to printed symptom management information versus elevated symptom management and telephone-based interpersonal counseling (TIP-C). The aim is to test the effects of these interventions on post-chemotherapy symptoms and symptom-specific responses to establish tailoring variables that can inform future personalized interventions and care.
Study Chair: Terry Badger, PhD; Alla Sikorskii, PhD
Study Co-Chairs: Tracy E. Crane, PhD, RDN
Clinical Trials Registration: NCT03494166
Status: Closed, expected publication 2022
Caregivers' and Cancer Survivors' Psychological Distress & Symptom Management
The SMART (randomized sequential assignment) trial design compares symptom assessment with supportive printed materials with coach-supported symptom management and telephone-based interpersonal counseling (TIP-C) for both survivors and their informal caregivers.
Study Chair: Terry Badger, PhD; Tracy E. Crane, PhD, RDN
Clinical Trials Registration: NCT03743415
Status: Closed, expected publication 2022
Improving Adherence to ACS Guidelines on Nutrition and Physical Activity in Latinas With Cancer and Their Informal Caregivers: the Nuestra Salud randomized pilot trial
This research study tested the feasibility and acceptability of a 12-week intervention that integrated telephone coaching and printed materials about the ACS guidelines and healthy lifestyle behaviors in order to manage symptoms after treatment for cancer.
Study Chair: Tracy E. Crane, PhD, RD
Study Co-Chair: Cynthia A. Thomson, RD, PhD
Clinical Trials Registration: NCT04314479
Status: Closed, published
The Lifestyle Intervention for Ovarian Cancer Enhanced Survival (LIVES) Study
This randomized phase III trial studied whether changes in diet and physical activity can increase the length of survival without the return of cancer (progression-free survival) compared with usual care in patients with previously treated stage II, III, or IV ovarian, fallopian tube, or primary peritoneal cancer. A healthy diet and physical activity program and counseling may help patients make healthier lifestyle choices.
Study Chair: David S. Alberts, MD
Study Co-Chairs: Cynthia A. Thomson, PhD, RD; Robert Mannel, MD; Tracy E. Crane, PhD, RD; Joan Walker, MD; Dana Chase, MD; Karen Basen-Engquist, PhD, MPH
Clinical Trials Registration: NCT00719303
Status: Closed, expected publication in 2023
S1820: Altering Intake, Managing Symptoms for Rectal Cancer (AIMS-RC) Survivors
This phase II trial studies how a diet intervention works in improving bowel dysfunction symptoms related in colon or rectal cancer survivors. Changing a diet may be helpful in reducing the severity of bowel symptoms, including diarrhea and constipation, and improve quality of life in colon or rectal cancer survivors and help doctors learn how to help patients better in the future.
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Virginia Sun, PhD, RN (PI), Tracy Crane, PhD, RDN (Co-I), Cynthia A. Thomson, PhD, RDN (Co-I); Robert S. Krouse, MD (Co-I)
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City of Hope, University of Arizona
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Recruiting Status: Closed
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Clinical Trials Registration: NCT04205955
Recent Scientific Publications from the CRANE Lab
1. Altering Intake and Managing Symptoms: Feasibility of a Diet Modification Intervention for Post-Treatment Bowel Dysfunction in Rectal Cancer
View in: PubMed
2. Use of scheduled and unscheduled health services by cancer survivors and their caregivers
View in: PubMed
3. Healthy lifestyle index and risk of pancreatic cancer in the Women’s Health Initiative
View in: PubMed
4. Social and Cultural Factors, Self-efficacy, and Health in Latino Cancer Caregivers
View in: PubMed
5. The Online Cancer Nutrition Misinformation: A framework of behavior change based on exposure to cancer nutrition misinformation
View in: PubMed
6. Attention to diet, exercise, and weight in oncology care: Results of an American Society of Clinical Oncology national patient survey
View in: PubMed
7. Trends in the Incidence of Upper Gastrointestinal Cancers Show Changing Dynamics
View in: PubMed
8. The relationship between sleep and weight change among women diagnosed with breast cancer participating in the Women’s Health Initiative
View in: PubMed
9. Role of dietary patterns and acculturation in cancer risk and mortality among postmenopausal Hispanic women: results from the Women’s Health Initiative (WHI)
View in: PubMed
10. American Cancer Society nutrition and physical activity guideline for cancer survivors
View in: PubMed
11. Implementation and Feasibility of an Electronic Health Record–Integrated Patient-Reported Outcomes Symptom and Needs Monitoring Pilot in Ambulatory Oncology
View in: PubMed
12. A phase III randomized trial of weight loss to reduce cancer-related fatigue among overweight and obese breast cancer patients: MEDEA Study design
View in: PubMed
13. Barriers and facilitators for adopting a healthy lifestyle among Latina cancer survivors: A qualitative descriptive study
View in: PubMed
14. Cardiometabolic risk factors, physical activity, and postmenopausal breast cancer mortality: results from the Women’s Health Initiative
View in: PubMed
15. COVID-19 Infection, the COVID-19 Pandemic, and Changes in Sleep
View in: PubMed
11. The Breast Cancer Weight Loss trial (Alliance A011401): A description and evidence for the lifestyle intervention
View in: PubMed
12. Relationship Between Individual Health Beliefs and Fruit and Vegetable Intake and Physical Activity Among Cancer Survivors: Results from the Health Information National Trends Survey
View in: PubMed