Post-chemotherapy Symptom Management: Testing Intervention Sequences in a SMART Design

The SMART (randomized sequential assignment) trial design incorporates two interventions with proven efficacy: symptom assessment and referral to printed symptom management information versus elevated symptom management and telephone-based interpersonal counseling (TIP-C). The aim is to test the effects of these interventions on post-chemotherapy symptoms and symptom-specific responses to establish tailoring variables that can inform future personalized interventions and care.