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Ongoing Research

Trial of Exercise and Lifestyle (TEAL) for Ovarian Cancer Survivors

 

 

This is a National Cancer Institute-sponsored study for newly diagnosed ovarian cancer survivors at University of Miami and Yale University. This study will explore the effects
of an 18-week medical nutrition and exercise therapy program during chemotherapy for ovarian cancer patients to improve chemotherapy completion and quality of life.

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  • Tracy Crane, PhD, RDN (MPI) and Melinda Irwin, PhD, MPH (MPI)

  • University of Miami and Yale University

  • Recruiting Status: Active

  • Clinical Trials Registration: NCT05761561

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Lifestyle Interventions of Food and Exercise for Lymphoma Survivors
(LIFE-L)

 

This is a study for newly diagnosed lymphoma cancer patients at the University of Miami. This work is support by the V Foundation for Cancer Research. This study will explore whether a healthy diet and increased physical activity can improve outcomes from treatment, including reducing side effects from chemotherapy and improving well-being and quality of life.

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  • Tracy Crane, PhD, RDN (MPI) and Craig Moskowitz, MD (MPI)

  • University of Miami

  • Recruitment Status: Active

  • Clinical Trials Registration: NCT05839210

Precision Oncology Interventions in Nutrition and Training (OnPOINT)

 

This is study is funded by the Applebaum Foundation for breast, prostate, and colorectal cancer survivors at the University of Miami. This study will explore if a tailored intervention on diet and physical activity can improve adherence to the current recommendations and improve quality of life, physical function, nutrition, and body composition. It is an 8-week program and participants are placed based in one of three groups based on their complexity needs.

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  • Tracy Crane, PhD, RDN (MPI)

  • University of Miami

  • Recruitment Status: Anticipated August 2023

  • Clinical Trials Registration: Pending

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Prolonged Overnight Fasting and/or Exercise on Fatigue and Other Patient Reported Outcomes in Women with Hormone Receptor Positive Advanced Breast Cancer 

 

This is a National Cancer Institute-sponsored study to explore the effect of fasting, exercise, or a combination of fasting and exercise, on fatigue in women with metastatic breast cancer. Additional outcomes will explore biomarkers of inflammation, quality of life, treatment toxicities, physical function and body composition. 

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  • Tracy Crane, PhD, RDN (MPI), Christina Dieli-Conwright, PhD (MPI), and Jennifer Ligibel, MD (MPI)

  • University of Miami, Dana-Farber Cancer Institute

  • Recruitment Status: Pending 

  • Clinical Trials Registration: Pending

FastER

NRG-CC012CD: Managing Symptoms and Psychological Distress During Oral Anti-Cancer Treatment

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This is a NCI-funded and NRG-supported study for patients who are receiving oral chemotherapy treatments for cancer. This study will recruit from 12 cancer clinics across the U.S. and will utilize an automated telephone symptom reporting system to help the patients report their side effects from treatment to their healthcare team. Additionally, patients may receive a psychosocial intervention for elevated symptoms of anxiety and distress. 

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  • Tracy Crane, PhD, RDN (MPI), 
    Alla Sikorskii, PhD (MPI), and Terry Badger, PhD (MPI)

  • Michigan State University, University of Miami, University of Arizona

  • Recruitment Status: Anticipated January 2024

  • Clinical Trials Registration: Pending

The Comparative Effectiveness of Lifestyle Interventions for Older Cancer Survivors and their Caregivers 

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This is PCORI-funded project to compare the effectiveness of a virtually supervised versus remotely monitored diet and exercise intervention on cognitive and physical function in cancers survivors older than 65 years and their caregivers . 

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  • Tracy Crane, PhD, RDN (MPI) and Christina Dieli-Conwright, PhD

  • Dana-Farber Cancer Institute, University of Miam

  • Recruitment Status: Pending

  • Clinical Trials Registration: Pending

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VITALITY

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Home-Based Telemonitoring Program for Functional Recovery and Symptoms in Cancer patients Undergoing Abdominal Surgery

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This phase III trial compares a home-based telemonitoring program that collects symptom and daily step information to surgeon only care in improving recovery and stopping complications within 30 days after surgery in patients with gastrointestinal, genitourinary, or gynecologic cancer who are scheduled to undergo abdominal surgery. This may help doctors and nurses find and treat problems early, which may improve the patient's recovery and lower the number of complications after surgery.

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  • Virginia Sun, PhD, RN (PI), Tracy Crane, PhD, RDN (Co-I)

  • City of Hope, University of Miami

  • Recruiting Status: Actively recruiting via City of Hope Comprehensive Cancer Center

  • Clinical Trials Registration: NCT04596384

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A Secondary Analysis of the LIvES Study (GOG 0225) using Natural Language Processing (NLP) and Machine Learning

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This is a secondary analysis of telephone coaching recordings from the Lifestyle Intervention for oVarian Cancer Enhanced Survival (LIvES) Study, GOG 0225, using natural language processing and machine learning to automate coaching protocol fidelity and use sentiment analysis to better predict behavior change outcomes.

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  • Tracy Crane, PhD, RDN (MPI) and Steven Bethard, PhD (MPI)

  • University of Miami and University of Arizona

  • Recruiting Status: N/A

Motivating to Exercise and Diet, and Educating to Healthy Behaviors After Breast Cancer (MEDEA)

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This is a phase III randomized controlled trial of a weight loss intervention in breast cancer survivors to reduce fatigue. Having an elevated BMI is a risk factor for cancer-related fatigue, which is the most common symptom during and after cancer treatments. This 12-month weight loss intervention incorporates coaching on diet quality, physical activity, and overall healthy behaviors. 

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  • Inez Vas Louis, MD (PI), Tracy E. Crane, PhD, RDN (Co-I), et al.

  • Gustave Roussy, Cancer Campus, Grand Paris

  • Recruiting Status: Actively recruiting via Gustave Roussy Cancer Campus

  • Clinical Trials Registration: NCT04304924

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Implementation of an Electronic Health Record–Integrated Patient-Reported Outcomes Symptom and Needs Monitoring Pilot (My Wellness Check) in Ambulatory Oncology

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My Wellness Check is a brief assessment, assigned to patients in the ambulatory oncology clinics at Sylvester Comprehensive Cancer Center, was designed to assess physical and psychologic symptoms and needs prior to appointments to triage them for additional supportive services. 

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  • Frank Penedo, PhD (PI), Tracy E. Crane, PhD, RDN (Co-I)

  • University of Miami

  • Recruiting Status: N/A

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